Brand name(s): Prilosec, Losec, Antra, Gastroloc, Mopral, Omepral.
Generic name(s): Omeprazole.
Street name(s), if any: None.
Available form(s): Oral, IV (Europe only).
Available dose(s): 10mg, 20mg, 40mg, 80mg.
North American availability: Available by prescription only in Canada and the United States.
Class(es): Proton pump inhibitor.
Method(s) of action: Reduces gastric acid production.
Most commonly prescribed for: Dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, Zollinger-Ellison syndrome.
Also prescribed for: Elimination of Helicobacter pylori infections.
Possible side effect(s): Anaphylaxis, anaphylactic shock, angioedema, bronchospasm, interstitial nephritis, urticaria, fever, pain, fatigue, malaise, chest pain or angina, tachycardia, bradycardia, palpitations, elevated blood pressure, peripheral edema, gynecomastia, pancreatitis, anorexia, irritable colon, fecal discolouration, esophageal candidiasis, mucosal atrophy of the tongue, stomatitis, abdominal swelling, dry mouth, liver disease, liver necrosis, hepatic encephalopathy hepatocellular disease, cholestatic disease, mixed hepatitis, jaundice, elevations of liver function tests, hypoglycemia, hyponatremia, weight gain, muscle weakness, myalgia, muscle cramps, joint pain, leg pain, depression, agitation, aggression, hallucinations, confusion, insomnia, nervousness, apathy, somnolence, anxiety, abnormal dreams, tremors, paresthesia, vertigo, epistaxis, pharyngeal pain, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, photosensitivity, rash, skin inflammation, pruritus, petechiae, purpura, alopecia, dry skin, hyperhidrosis, tinnitus, taste perversion, optic atrophy, anterior ischemic optic neuropathy, optic neuritis, dry eye syndrome, ocular irritation, blurred vision, double vision, hematuria, proteinuria, elevated serum creatinine, microscopic pyuria, urinary tract infection, glycosuria, urinary frequency, testicular pain, agranulocytosis, hemolytic anemia, pancytopenia, neutropenia, anemia, thrombocytopenia, leukopenia, leukocytosis.
Possibility of tolerance: None known.
Addictive potential: None.
Withdrawal potential: None (although underlying symptoms may return).
Withdrawal symptoms: None.
Potential for abuse/misuse: None.
Drug interaction(s): Omeprazole interferes with many antiretroviral drugs. It may interfere with the absorption of drugs that rely on certain gastric pH levels, such as Ketoconazole, Ampicillin esters, and iron salts. Dosage of drugs such as Cyclosporine, Disulfiram, and benzodiazepines may need to be adjusted. Simultaneous use of Omeprazole and Tacrolimus may increase serum levels of Tacrolimus.
Contraindication(s): Omeprazole is contraindicated in anyone who may have a hypersensitivity to any of its ingredients.
Overdose threshold: Unknown.
Symptoms of overdose: Confusion, drowsiness, blurred vision, tachycardia, nausea, vomiting, diaphoresis, flushing, headache, dry mouth.
